Parity, Lactation, Bone Strength, and 16-year Fracture Risk in Adult Women: Findings From the Study of Women’s Health Across the Nation (SWAN)
Identifieur interne : 001C45 ( Main/Exploration ); précédent : 001C44; suivant : 001C46Parity, Lactation, Bone Strength, and 16-year Fracture Risk in Adult Women: Findings From the Study of Women’s Health Across the Nation (SWAN)
Auteurs : Takahiro Mori [Japon] ; Shinya Ishii [Japon] ; Gail A. Greendale [États-Unis] ; Jane A. Cauley [États-Unis] ; Kristine Ruppert [États-Unis] ; Carolyn J. Crandall [États-Unis] ; Arun S. Karlamangla [États-Unis]Source :
- Bone [ 8756-3282 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- physiologie : Os et tissu osseux.
- épidémiologie : Fractures osseuses, États-Unis d'Amérique.
- Adulte, Adulte d'âge moyen, Facteurs de risque, Femelle, Humains, Parité, Santé des femmes, Études prospectives.
- Wicri :
- geographic : États-Unis.
English descriptors
- KwdEn :
- MESH :
- geographic , epidemiology : United States.
- epidemiology : Fractures, Bone.
- physiology : Bone and Bones.
- Adult, Female, Humans, Middle Aged, Parity, Prospective Studies, Risk Factors, Women's Health.
Abstract
Our objective was to examine the associations of lifetime parity and accumulated length of lactation with bone strength in women prior to the menopause transition and fracture risk during and after the transition. Participants were 2239 pre- or early perimenopausal women from the Study of Women's Health Across the Nation (SWAN), ages 42–53 at baseline, who had no childbirths after age 42. Bone mineral density (BMD) was measured in the femoral neck and the lumbar spine at the baseline SWAN visit using dual-energy x-ray absorptiometry, and composite indices of femoral neck strength relative to load (in three failure modes: compression, bending, and impact) were calculated from femoral neck BMD, femoral neck size, and body size. Data on fractures after age 42 were collected for a median follow-up of 15.7 years (interquartile range, 11.4 –18.5 years). In multiple linear regression adjusted for covariates, lifetime parity was associated positively with femoral neck strength relative to load (0.024 standard deviation (SD) increment in impact strength index per childbirth, p= 0.049), but accumulated length of lactation was associated negatively with lumbar spine BMD (0.018 SD decrement per every additional 6 months of lactation p=0.040). In Cox proportional hazards regression adjusted for covariates, neither parity nor lactation was associated with fracture hazard after age 42. In conclusion, parity and lactation have little impact on peak bone strength prior to menopause, and do not affect fracture risk after age 42 over 16-year follow-up.
Url:
DOI: 10.1016/j.bone.2014.12.013
PubMed: 25528102
PubMed Central: 4364696
Affiliations:
- Japon, États-Unis
- Pennsylvanie, Région de Kantō
- Pittsburgh, Tokyo
- Université de Pittsburgh, Université de Tokyo
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Le document en format XML
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Greendale</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Medicine/Division of Geriatrics, David Geffen School of Medicine at UCLA, 10945 Le Conte Ave, Ste. 2339, Los Angeles CA 90095, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine/Division of Geriatrics, David Geffen School of Medicine at UCLA, 10945 Le Conte Ave, Ste. 2339, Los Angeles CA 90095</wicri:regionArea><wicri:noRegion>Los Angeles CA 90095</wicri:noRegion></affiliation></author><author><name sortKey="Cauley, Jane A" sort="Cauley, Jane A" uniqKey="Cauley J" first="Jane A." last="Cauley">Jane A. Cauley</name><affiliation wicri:level="4"><nlm:aff id="A4">Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, A510 Crabtree Hall, Pittsburgh PA 15260, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, A510 Crabtree Hall, Pittsburgh PA 15260</wicri:regionArea><orgName type="university">Université de Pittsburgh</orgName><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Ruppert, Kristine" sort="Ruppert, Kristine" uniqKey="Ruppert K" first="Kristine" last="Ruppert">Kristine Ruppert</name><affiliation wicri:level="4"><nlm:aff id="A4">Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, A510 Crabtree Hall, Pittsburgh PA 15260, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, A510 Crabtree Hall, Pittsburgh PA 15260</wicri:regionArea><orgName type="university">Université de Pittsburgh</orgName><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Crandall, Carolyn J" sort="Crandall, Carolyn J" uniqKey="Crandall C" first="Carolyn J." last="Crandall">Carolyn J. Crandall</name><affiliation wicri:level="1"><nlm:aff id="A5">Department of Medicine/Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine at UCLA, 911 Broxton Ave, 1st floor, Los Angeles CA 90024, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine/Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine at UCLA, 911 Broxton Ave, 1st floor, Los Angeles CA 90024</wicri:regionArea><wicri:noRegion>Los Angeles CA 90024</wicri:noRegion></affiliation></author><author><name sortKey="Karlamangla, Arun S" sort="Karlamangla, Arun S" uniqKey="Karlamangla A" first="Arun S." last="Karlamangla">Arun S. Karlamangla</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Medicine/Division of Geriatrics, David Geffen School of Medicine at UCLA, 10945 Le Conte Ave, Ste. 2339, Los Angeles CA 90095, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine/Division of Geriatrics, David Geffen School of Medicine at UCLA, 10945 Le Conte Ave, Ste. 2339, Los Angeles CA 90095</wicri:regionArea><wicri:noRegion>Los Angeles CA 90095</wicri:noRegion></affiliation></author></analytic><series><title level="j">Bone</title><idno type="ISSN">8756-3282</idno><idno type="eISSN">1873-2763</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Bone and Bones (physiology)</term><term>Female</term><term>Fractures, Bone (epidemiology)</term><term>Humans</term><term>Middle Aged</term><term>Parity</term><term>Prospective Studies</term><term>Risk Factors</term><term>United States (epidemiology)</term><term>Women's Health</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Facteurs de risque</term><term>Femelle</term><term>Fractures osseuses (épidémiologie)</term><term>Humains</term><term>Os et tissu osseux (physiologie)</term><term>Parité</term><term>Santé des femmes</term><term>États-Unis d'Amérique (épidémiologie)</term><term>Études prospectives</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>United States</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Fractures, Bone</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Os et tissu osseux</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Bone and Bones</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Fractures osseuses</term><term>États-Unis d'Amérique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Middle Aged</term><term>Parity</term><term>Prospective Studies</term><term>Risk Factors</term><term>Women's Health</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Parité</term><term>Santé des femmes</term><term>Études prospectives</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>États-Unis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Our objective was to examine the associations of lifetime parity and accumulated length of lactation with bone strength in women prior to the menopause transition and fracture risk during and after the transition. Participants were 2239 pre- or early perimenopausal women from the Study of Women's Health Across the Nation (SWAN), ages 42–53 at baseline, who had no childbirths after age 42. Bone mineral density (BMD) was measured in the femoral neck and the lumbar spine at the baseline SWAN visit using dual-energy x-ray absorptiometry, and composite indices of femoral neck strength relative to load (in three failure modes: compression, bending, and impact) were calculated from femoral neck BMD, femoral neck size, and body size. Data on fractures after age 42 were collected for a median follow-up of 15.7 years (interquartile range, 11.4 –18.5 years). In multiple linear regression adjusted for covariates, lifetime parity was associated positively with femoral neck strength relative to load (0.024 standard deviation (SD) increment in impact strength index per childbirth, p= 0.049), but accumulated length of lactation was associated negatively with lumbar spine BMD (0.018 SD decrement per every additional 6 months of lactation p=0.040). In Cox proportional hazards regression adjusted for covariates, neither parity nor lactation was associated with fracture hazard after age 42. In conclusion, parity and lactation have little impact on peak bone strength prior to menopause, and do not affect fracture risk after age 42 over 16-year follow-up.</p></div></front></TEI><affiliations><list><country><li>Japon</li><li>États-Unis</li></country><region><li>Pennsylvanie</li><li>Région de Kantō</li></region><settlement><li>Pittsburgh</li><li>Tokyo</li></settlement><orgName><li>Université de Pittsburgh</li><li>Université de Tokyo</li></orgName></list><tree><country name="Japon"><noRegion><name sortKey="Mori, Takahiro" sort="Mori, Takahiro" uniqKey="Mori T" first="Takahiro" last="Mori">Takahiro Mori</name></noRegion><name sortKey="Ishii, Shinya" sort="Ishii, Shinya" uniqKey="Ishii S" first="Shinya" last="Ishii">Shinya Ishii</name></country><country name="États-Unis"><noRegion><name sortKey="Greendale, Gail A" sort="Greendale, Gail A" uniqKey="Greendale G" first="Gail A." last="Greendale">Gail A. Greendale</name></noRegion><name sortKey="Cauley, Jane A" sort="Cauley, Jane A" uniqKey="Cauley J" first="Jane A." last="Cauley">Jane A. Cauley</name><name sortKey="Crandall, Carolyn J" sort="Crandall, Carolyn J" uniqKey="Crandall C" first="Carolyn J." last="Crandall">Carolyn J. Crandall</name><name sortKey="Karlamangla, Arun S" sort="Karlamangla, Arun S" uniqKey="Karlamangla A" first="Arun S." last="Karlamangla">Arun S. Karlamangla</name><name sortKey="Ruppert, Kristine" sort="Ruppert, Kristine" uniqKey="Ruppert K" first="Kristine" last="Ruppert">Kristine Ruppert</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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